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Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion | PNAS
Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion | PNAS

Frontiers | Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology
Frontiers | Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology

Counteracting CAR T cell dysfunction | Oncogene
Counteracting CAR T cell dysfunction | Oncogene

PDF] Strategies to Address Chimeric Antigen Receptor Tonic Signaling | Semantic Scholar
PDF] Strategies to Address Chimeric Antigen Receptor Tonic Signaling | Semantic Scholar

Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness | Cell Research
Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness | Cell Research

Context matters in CAR T cell tonic signaling | Nature Medicine
Context matters in CAR T cell tonic signaling | Nature Medicine

Tonic Signals: Why Do Lymphocytes Bother?
Tonic Signals: Why Do Lymphocytes Bother?

New mechanism in preventing CAR-T cell exhaustion
New mechanism in preventing CAR-T cell exhaustion

PDF] Strategies to Address Chimeric Antigen Receptor Tonic Signaling | Semantic Scholar
PDF] Strategies to Address Chimeric Antigen Receptor Tonic Signaling | Semantic Scholar

Scientists in the SLST and collaborators develop a CAR rational design platform
Scientists in the SLST and collaborators develop a CAR rational design platform

CAR-T design: Elements and their synergistic function - eBioMedicine
CAR-T design: Elements and their synergistic function - eBioMedicine

Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion | PNAS
Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion | PNAS

TCR-like platform – Lentistem Biotech
TCR-like platform – Lentistem Biotech

Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy | Journal of Hematology & Oncology | Full Text
Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy | Journal of Hematology & Oncology | Full Text

Tonic Signaling and Its Effects on Lymphopoiesis of CAR-Armed Hematopoietic Stem and Progenitor Cells
Tonic Signaling and Its Effects on Lymphopoiesis of CAR-Armed Hematopoietic Stem and Progenitor Cells

Tonic GD2.28z CAR signaling is antigen independent. (a) In vitro 51Cr... | Download Scientific Diagram
Tonic GD2.28z CAR signaling is antigen independent. (a) In vitro 51Cr... | Download Scientific Diagram

Rational Tuning of CAR Tonic Signaling Yields Superior T-Cell Therapy for Cancer | bioRxiv
Rational Tuning of CAR Tonic Signaling Yields Superior T-Cell Therapy for Cancer | bioRxiv

Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness | Cell Research
Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness | Cell Research

Tonic Signals: Why Do Lymphocytes Bother?
Tonic Signals: Why Do Lymphocytes Bother?

Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling | Science
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling | Science

Jacob Plieth on X: "Max Mamonkin (Baylor) suggesting CAR clustering as a reason for tonic signalling (i.e., signal in absence of antigen) #CARTCR https://t.co/Lmwld40Iue" / X
Jacob Plieth on X: "Max Mamonkin (Baylor) suggesting CAR clustering as a reason for tonic signalling (i.e., signal in absence of antigen) #CARTCR https://t.co/Lmwld40Iue" / X

Exhaustion of CAR T cells: potential causes and solutions | Journal of Translational Medicine | Full Text
Exhaustion of CAR T cells: potential causes and solutions | Journal of Translational Medicine | Full Text

Tonic Signaling and Its Effects on Lymphopoiesis of CAR-Armed Hematopoietic Stem and Progenitor Cells
Tonic Signaling and Its Effects on Lymphopoiesis of CAR-Armed Hematopoietic Stem and Progenitor Cells

Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent - ScienceDirect
Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent - ScienceDirect

Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent - ScienceDirect
Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent - ScienceDirect

Signal transduction underlying chimeric antigen receptor (CAR)-induced... | Download Scientific Diagram
Signal transduction underlying chimeric antigen receptor (CAR)-induced... | Download Scientific Diagram